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Fat Loss Formula | How to Use GKI to Enhance the Keto Diet | Glucose Ketone Index Explained
The GKI, or the Glucose Ketone Index, is a formula that tracks the ratio of blood glucose to ketones as a single value – it’s a biomarker for tracking your metabolic health as well as your level of ketosis.
Use in Studies:
Developed by Dr. Thomas Seyfried for management of brain cancer-
Was created to track the zone of metabolic management for brain tumor management
Study #1 – Journal of the American College of Nutrition:
The first study evaluated two pediatric patients; one with an anaplastic astrocytoma, and another with a cerebellar astrocytoma – both individuals were placed on a keto diet for 8 weeks. During the 8-week treatment period, GKI dropped from about 27.5 to about 0.7 – 1.1 in the patients. The patient with the anaplastic astrocytoma, who did not have a response to prior chemotherapy, had a 21.7% reduction in fluorodeoxyglucose uptake at the tumor site (no chemotherapy during diet.) The patient with the cerebellar astrocytoma received standard chemotherapy concomitant with the ketogenic diet.
Fluorodeoxyglucose uptake at the tumor site in this patient was reduced by 21.8% – quality of life was markedly improved in both children after initiation of the KD. The patient’s GKI decreased from 37.5 to 1.4 in the first three weeks of the diet. No discernible brain tumor tissue was detected with MRI in the patient at the end of eight weeks of the calorie restricted ketogenic diet. It is also important to mention that the patient was free of symptoms while she adhered to the KD – tumor recurrence occurred 10 weeks after suspension of the ketogenic diet.
**The glucose ketone index isn’t just for cancer treatment. This value is also of importance for people who have blood sugar issues. The GKI also isn’t just for ketosis.**
On Exercise: It is healthy for blood sugar to rise during exercise because the muscles need the excess fuel to compensate for the increased demand placed upon them. But in most people the body will adjust after exercising and bring the blood sugar levels back to normal.
On Fasting: Tracking the glucose ketone index can be a very helpful piece of biofeedback to understand how your metabolism is responding during the fasting period. Over time, you can look back at different fasting periods and use the index as an indicator of your metabolic state during the course of the fasting period.
With Food: **Blood glucose and ketone values should be measured 2–3 hours postprandial, twice a day if possible – allows individuals to connect their dietary intake to changes in their GKI**
(Your Glucose Level / 18) / Your Ketones Level = Your Glucose Ketone Index.
You divide the glucose number by 18 because glucose readings in the U.S. are measured in mg/dL, and dividing by 18 converts that number to mmol/L to match your ketones reading.
1) The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367849/
2) The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. (n.d.). Retrieved from https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0009-2
3) Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. (2013, September 4). Retrieved from https://www.tandfonline.com/doi/abs/10.1080/07315724.1995.10718495
4) Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. (n.d.). Retrieved from https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-
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